Strobel, whose apologetics titles The Case for Christ and The Case for Faith have enjoyed strong popularity among evangelicals, approaches creation/evolution issues in the same simple and energetic style. The format will be familiar to readers of previous Case books: Strobel visits with scholars and researchers and works each interview into a topical outline.

Although Strobel does not interview any "hostile" witnesses, he exposes readers to the work of some major origins researchers (including Jonathan Wells, Stephen Meyer and Michael Behe) and theistic philosophers (including William Lane Craig and J. P. Moreland). Strobel claims no expertise in science or metaphysics, but as an interviewer he makes this an asset, prodding his sources to translate jargon and provide illustrations for their arguments.